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Lee Laboratory

UTHealth School of Dentistry Research Labs

Overview

Periodontitis is a biofilm induced chronic inflammatory disease that is characterized by gingival inflammation and alveolar bone loss around teeth. According to the 2009-2014 National Health and Nutrition Examination Survey (NHANES), around 61 million adults over 30 years-old have periodontitis (42.2%) with 7.8% having severe periodontitis. Dr. Chun-Teh Lee’s research focuses on understanding resolution of inflammation mediated by specialized pro-resolving mediators (SPMs) in periodontitis. His work demonstrated that control of inflammation biochemically by SPM has a direct impact on the composition of the subgingival microbiota, gene expression pattern in gingival tissue and reverses periodontal disease progression in the preclinical model. Recently, he is investigating correlations between profiles of SPMs, SPM pathway markers, SPM corresponding receptor gene expression in gingiva and subgingival microbiome in periodontal inflammation and the impact of SPMs on celluar activities. Dr. Lee is also active in studying periodontal disease diagnosis, periodontal disease risk assessment, novel therapy in periodontology and implantology, precision dentistry and evidence-based dentistry.

Projects

  • Improving Periodontal Health through a Precision Periodontal Health Care Chart

    Improving Periodontal Health through a Precision Periodontal Health Care Chart

    The project aims to develop a Precision Periodontal Health Care Chart (PPHCC) consisting of the information on risk factors and risk assessment. The evidence-based information on risk factors will be provided to educate and motivate patients. A risk assessment tool for periodontitis will be developed and a risk profile can be assigned to each patient based on the patient history and clinical examinations.

  • The Profile of Specialized Proresolving Lipid Mediators and Their Association with Subgingival Microbiota in Periodontitis

    The Profile of Specialized Proresolving Lipid Mediators and Their Association with Subgingival Microbiota in Periodontitis

    This project aims to identify and quantify SPMs and their receptors in gingiva of subjects with periodontitis compared to subjects with healthy periodontium and understand the relationship between profiles of SPMs and subgingival microbiota.

  • Bioactive Tissue Graft Replacement for Regeneration of Gingiva

    Bioactive Tissue Graft Replacement for Regeneration of Gingiva

    This study aims to develop a bioactive tissue graft replacement prototype for the application in the mucogingival plastic surgery. The bioactive tissue graft replacement is a hyaluronic acid-based hydrogel loaded with resolvin E1 potentially can support and augment gingiva and promote periodontal tissue regeneration.

Lab Team

Chun-Teh Lee, DDS, DMSc, MS
Associate Professor; Director of Periodontics Research
Chun-Teh.Lee@uth.tmc.edu
713-486-4384
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 - Photo not availableJiman Nelson, DMD, MS
Third-Year Resident
Jiman.Nelson@uth.tmc.edu


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 - Photo not availableMary Jung, DDS
Second-Year Resident
Mary.H.Jung@uth.tmc.edu


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Key Publications

Abstracts:

1. Chun HB, Wu CY, Wu D, Harrington D, Farach-Carson M, Lee CT. Impact of Resolvin E1 on Human Gingival Fibroblast Growth. Poster presentation, 98th General Session & Exhibition of the International Association for Dental Research (IADR), 2020 March

2. Lee CT, Ferguson B, Zhu L, Tribble G, Zheng J W, Bokka N, Maddipati K, Ayilavarapu S, Angelov N, Van Dyke T. Profiling Inflammation Resolution and the Microbiome in Periodontitis. Abstract. 98th General Session & Exhibition of the IADR, 2020 March

Articles:

1. Lee CT, Teles R, Kantarci A, Chen T, McCafferty J, Starr J, Brito L, Paster B, Van Dyke T. Resolvin E1 Reverses Experimental Periodontitis and Dysbiosis. The Journal of Immunology, 2016 Oct 1; 197(7): 2796-806. PMID: 27543615; PMCID: PMC5026932.

2. Lee CT, Huang YW, Zhu L, Weltman R. Prevalences of Peri-implantitis and Peri-implant Mucositis: Systematic Review and Meta-Analysis. Journal of Dentistry, 2017 Jul;62:1-12. PMID: 28478213.

3. Hsu YT, Nair M, Angelov N, Lalla E, Lee CT. Impact of Diabetes on Clinical Periodontal Outcomes Following Non-Surgical Periodontal Therapy. Journal of Clinical Periodontology, 2019 Feb;46(2):206-217. PMID: 30536853. (Corresponding Author).

4. Osorio Parra MM, Satheesh E, Lee CT. Specialized Pro-Resolving Lipid Mediators in Experimental Periodontitis: A Systematic Review. Oral Diseases, 2019 Jul;25(5):1265-1276. PMID: 30230662.

5. Palanker N, Lee CT, Weltman R, Tribble G, van der Hoeven R, Hong JM, Wang BY. Antimicrobial Efficacy
Assessment of Human Derived Composite Amnion-Chorion Membrane. Scientific Reports, 2019, 9:15600.
PMID: 31666625. PMCID: PMC6821917.

6. Ferguson B, Bokka N, Maddipati K, Ayilavarapu S, Weltman R, Zhu LS, Chen WQ, Zheng J. W, Angelov N, Van Dyke T, Lee CT. Distinct Profiles of Specialized Pro-Resolving Lipid Mediators and Corresponding Receptor Gene Expression in Periodontal Inflammation. Frontiers in Immunology. 2020 Jun 25;11:1307. PMID: 32670289. PMCID: PMC7330171.

7. Lee CT, Sanz E, Zhu L, Glick J, Heath A, Stoupel J. Predicting Bone and Soft Tissue Alterations of Immediate Implant Sites in the Esthetic Zone Using Clinical Parameters. Clinical Implant Dentistry and Related Research, 2020 Jun;22(3):325-332. PMID: 32346981.
Overall publication: https://www.ncbi.nlm.nih.gov/myncbi/14G2dvVs_BEAA/bibliography/public/; https://scholar.google.com/citations?user=7aqd_vsAAAAJ&hl=en

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